Abstract\r\nBackground: Cardiovascular disease is a major cause of death in patients with stage 4ââ?¬â??5 Chronic Kidney disease\r\n(CKD, eGFR < 30). There are only limited data on the risk factors predicting these complications in CKD patients. Our\r\naim was to determine the role of clinical and echocardiographic parameters in predicting mortality and\r\ncardiovascular complications in CKD patients.\r\nMethods: We conducted a prospective observational cohort study of 153 CKD patients between 2007 and 2009. All\r\npatients underwent echocardiography at baseline and were followed for a mean of 2.6 years using regular clinic\r\nvisits and review of files and hospital presentations to record the incidence of cardiovascular events and death.\r\nResults: Of 153 patients enrolled, 57 (37%) were on dialysis and 45 (78%) of these patients were on haemodialysis. An\r\nenlarged LV was present in 32% of patients and in 22% the LVEF was below 55%. LV mass index was increased in 75%\r\nof patients. Some degree of diastolic dysfunction was present in 85% of patients and 35% had grade 2 or higher\r\ndiastolic dysfunction. During follow up 41 patients (27%) died, 15 (39%) from cardiovascular causes. Mortality was 24.0%\r\nin the non-dialysis patients versus 31.6% in patients on dialysis (p=ns). On multivariate analysis age >75 years, previous\r\nhistory of MI, diastolic dysfunction and detectable serum troponin T were significant independent predictor of mortality\r\n(P < 0.01).\r\nConclusion: Patients with stage 4ââ?¬â??5 CKD had a mortality rate of 27% over a mean follow up of 2.6 years.\r\nAge >75 years, history of MI, diastolic dysfunction and troponin T were independent predictors of mortality.
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